Selective Na(V)1.1 activation rescues Dravet syndrome mice from seizures and premature death
Kay L Richards, Carol J Milligan, Robert J Richardson, Nikola Jancovski, Morten Grunnet, Laura H Jacobson, Eivind AB Undheim, Mehdi Mobli, Chun Yuen Chow, Volker Herzig, Agota Csoti, Gyorgy Panyi, Christopher A Reid, Glenn F King, Steven Petrou
Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2018
Awarded by Citizen's United for Research in Epilepsy Pediatrics Award
Awarded by Australian National Health and Medical Research Council Program
Awarded by European Union
We thank Prof. Kazuhiro Yamakawa (RIKEN Brain Science Institute) for donating Dravet syndrome mice and Prof. Gilles Guillemin (St Vincent's Centre for Applied Medical Research) for human CSF. This work was supported by Citizen's United for Research in Epilepsy Pediatrics Award 353711, Australian National Health and Medical Research Council Program Grant 10915693 (to S.P. and C.A.R.), Principal Research Fellowships (to S.P. and G.F.K.), an Australian Research Council Discovery Early Career Researcher Award Fellowship (to E.A.B.U.), a Dowd Foundation Research Fellowship (to C.A.R.), and by the GINOP-2.3.2-15-2016-00044 Project cofinanced by the European Union and the European Regional Development Fund (G.P.). The Florey Institute of Neuroscience and Mental Health is supported by infrastructure funds from the Department of Health, State Government of Victoria.