Journal article

Biofabrication of human articular cartilage: a path towards the development of a clinical treatment

Carmine Onofrillo, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Andrea J O'Connor, Mark Scott, Gordon G Wallace, Peter FM Choong, Claudia Di Bella



Cartilage injuries cause pain and loss of function, and if severe may result in osteoarthritis (OA). 3D bioprinting is now a tangible option for the delivery of bioscaffolds capable of regenerating the deficient cartilage tissue. Our team has developed a handheld device, the Biopen, to allow in situ additive manufacturing during surgery. Given its ability to extrude in a core/shell manner, the Biopen can preserve cell viability during the biofabrication process, and it is currently the only biofabrication tool tested as a surgical instrument in a sheep model using homologous stem cells. As a necessary step toward the development of a clinically relevant protocol, we aimed to demonstrate that..

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Awarded by Australian Research Council Centre of Excellence Scheme

Funding Acknowledgements

This work was supported by (1) Arthritis Australia-Zimmer Australia Grant, (2) Victorian Orthopaedic Research Trust, (3) The John Loewenthal Foundation for Surgery (Royal Australasian College of Surgeons), (4) The Australian Research Council Centre of Excellence Scheme (Project Number CE 140100012), and (5) St Vincent's Hospital (Melbourne).Research Endowment Found. Equipment Grant form MTPConnect is gratefully acknowledged. Access to atomic force microscope facilities was provided through the Materials Characterisation and Fabrication Platform at the University of Melbourne.