Journal article
Replication-independent reduction in the number and diversity of recombinant progeny viruses in chickens vaccinated with an attenuated infectious laryngotracheitis vaccine
Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Glenn F Browning, Jose A Quinteros, Andres Diaz-Mendez, Dulari Thilakarathne, Omid Fakhri, Paola K Vaz, Joanne M Devlin
VACCINE | ELSEVIER SCI LTD | Published : 2018
Abstract
Recombination is closely linked with virus replication and is an important mechanism that contributes to genome diversification and evolution in alphaherpesviruses. Infectious laryngotracheitis (ILTV; Gallid alphaherpesvirus 1) is an alphaherpesvirus that causes respiratory disease in poultry. In the past, natural (field) recombination events between different strains of ILTV generated virulent recombinant viruses that have caused severe disease and economic loss in poultry industries. In this study, chickens were vaccinated with attenuated ILTV vaccines to examine the effect of vaccination on viral recombination and diversity following subsequent co-inoculation with two field strains of ILT..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the Australian Research Council (FT140101287). Carlos Loncoman is supported by Becas Chile, CONICYT, Gobierno de Chile. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. We acknowledge Mahathi Nadimpalli, Nino Ficorilli, Mesula Korsa, June Daly and Jenece Wheeler.