Journal article

Outcomes of endovascular thrombectomy with and without bridging thrombolysis for acute large vessel occlusion ischaemic stroke

Julian Maingard, Yasmin Shvarts, Ronan Motyer, Vincent Thijs, Paul Brennan, Alan O'Hare, Seamus Looby, John Thornton, Joshua A Hirsch, Christen D Barras, Ronil Chandra, Mark Brooks, Hamed Asadi, Hong K Kok

INTERNAL MEDICINE JOURNAL | WILEY | Published : 2019

Abstract

BACKGROUND: Endovascular thrombectomy (EVT) for management of large vessel occlusion (LVO) acute ischaemic stroke is now current best practice. AIM: To determine if bridging intravenous (i.v.) alteplase therapy confers any clinical benefit. METHODS: A retrospective study of patients treated with EVT for LVO was performed. Outcomes were compared between patients receiving thrombolysis and EVT with EVT alone. Primary end-points were reperfusion rate, 90-day functional outcome and mortality using the modified Rankin Scale (mRS) and symptomatic intracranial haemorrhage (sICH). RESULTS: A total of 355 patients who underwent EVT was included: 210 with thrombolysis (59%) and 145 without (41%). The ..

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