Episodic memory and learning dysfunction over an 18-month period in preclinical and prodromal Alzheimer's disease

JE Baker; YY Lim; J Jaeger; D Ames; NT Lautenschlager; J Robertson; RH Pietrzak; PJ Snyder; VL Villemagne; CC Rowe; CL Masters; P Maruff

Journal article

Episodic memory and learning dysfunction over an 18-month period in preclinical and prodromal Alzheimer's disease

JE Baker, YY Lim, J Jaeger, D Ames, NT Lautenschlager, J Robertson, RH Pietrzak, PJ Snyder, VL Villemagne, CC Rowe, CL Masters, P Maruff

Journal of Alzheimer S Disease | IOS PRESS | Published : 2018

DOI: 10.3233/JAD-180344

Abstract

Recent meta-analyses suggest that episodic memory impairment associated with preclinical Alzheimer's disease (AD) equates to 0.15-0.24 standard deviations below that of cognitively healthy older adults. The current study aimed to characterize impairments in verbal acquisition and recall detectable at a single assessment, and investigate how verbal learning and episodic memory deteriorates in preclinical AD. A verbal list-learning task, the International Shopping List Test (ISLT), was administered multiple times over an 18-month period, to three groups of participants: amyloid-beta negative healthy older adults (Aβ- CN; n = 50); Aβ+ positive healthy older adults (preclinical AD; n = 25); and ..

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University of Melbourne Researchers

David Ames Author

Nicola Lautenschlager Author

Victor Villemagne Author

Christopher Rowe Author

Grants

Funding Acknowledgements

Funding for the study was provided by AstraZeneca Pharmaceuticals LP, the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), The Mental Health Research Institute (MHRI), Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd, Hollywood Private Hospital, Sir Charles Gairdner Hospital. The study also receives funding from the National Health and Medical Research Council (NHMRC), the Dementia Collaborative Research Centres program (DCRC), The McCusker Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria. The authors acknowledge the financial support of the Cooperative Research Centre (CRC) for Mental Health. The CRC programme is an Australian Government Initiative. YYL reports grants from the National Health and Medical Research Council (GNT1111603, GNT 1147465). The ROCS team wishes to thank the participants in the ROCS study for their commitment and dedication to helping advance research into the early detection and causation of AD and the clinicians who referred patients to the study.