Diffusion weighted and dynamic contrast enhanced MRI as an imaging biomarker for stereotactic ablative body radiotherapy (SABR) of primary renal cell carcinoma
Hayley M Reynolds, Bimal K Parameswaran, Mary E Finnegan, Diana Roettger, Eddie Lau, Tomas Kron, Mark Shaw, Sarat Chander, Shankar Siva
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018
PURPOSE: To explore the utility of diffusion and perfusion changes in primary renal cell carcinoma (RCC) after stereotactic ablative body radiotherapy (SABR) as an early biomarker of treatment response, using diffusion weighted (DWI) and dynamic contrast enhanced (DCE) MRI. METHODS: Patients enrolled in a prospective pilot clinical trial received SABR for primary RCC, and had DWI and DCE MRI scheduled at baseline, 14 days and 70 days after SABR. Tumours <5cm diameter received a single fraction of 26 Gy and larger tumours received three fractions of 14 Gy. Apparent diffusion coefficient (ADC) maps were computed from DWI data and parametric and pharmacokinetic maps were fitted to the DCE data...View full abstract
Awarded by Contributing to Australia Scholarship and Science (CASS) Science and Medicine
Awarded by CASS Science and Medicine
This study was supported by a Contributing to Australia Scholarship and Science (CASS) Science and Medicine grant SM/11/3784 to SS (http://www.cassfoundation.org/) and a Ferring Pharmaceutical Fellowship Award from the Royal Australia and New Zealand College of Radiation Oncology (https://www.ranzcr.com/). Image Analysis Group provided support in the form of a salary for author Diana Roettger. The funders had no additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.This study was supported by a CASS Science and Medicine grant SM/11/3784, and the Royal Australia and New Zealand College of Radiation Oncology / Ferring Pharmaceutical Fellowship Award. The authors would like to gratefully acknowledge Noelene Bergen for assisting development of the MRI protocol, Price Jackson for imaging expertise and manuscript feedback, Mathias Bressel for providing statistical consultation and Teng Han Tan for carrying out CT tumour measurements.