Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model
Lloyd ML Smyth, Jacqueline F Donoghue, Jessica A Ventura, Jayde Livingstone, Tracy Bailey, Liam RJ Day, Jeffrey C Crosbie, Peter AW Rogers
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018
Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy (SBBR). Both of these modalities have unique physical properties that could be exploited for an improved therapeutic effect. While pre-clinical studies report promising normal tissue sparing phenomena, systematic toxicity data are still required. Our objective was to characterise the toxicity of SBBR and MRT and to calculate equivalent doses of conventional radiation therapy (CRT). A dose-escalation study was performed on C57BLJ/6 mice using total body and partial body irradiations. Dose-response curves and TD50 values w..View full abstract
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Awarded by NHMRC
The authors wish to acknowledge beam-time access from The Australian Synchrotron. We are grateful to Duncan Butler and the team at the Australian Radiation Protection and Nuclear Safety Agency for assistance with the CRT irradiations and dosimetry, Andrew Stevenson, Dr. Mitzi Klein, Helen Forrester and Claire Scott for support during SBBR and MRT irradiations at the IMBL, Leonie Cann for assistance in preparing tissue samples for histological analysis, Shenna Langenbach for interpretation of the lung histology and Andrew Naughton and the animal welfare team at the University of Melbourne. We are grateful to Trent Smith from The Australian Synchrotron for constructing the plastic mouse holders to position the mice. L.S. is supported by a Research Training Program scholarship from the Australian Government. This project was supported by a grant from the NHMRC [Project Grant 1061772].