Dietary intake of one-carbon metabolism nutrients and DNA methylation in peripheral blood
James A Chamberlain, Pierre-Antoine Dugue, Julie K Bassett, Allison M Hodge, Maree T Brinkman, JiHoon E Joo, Chol-Hee Jung, Enes Makalic, Daniel F Schmidt, John L Hopper, Daniel D Buchanan, Dallas R English, Melissa C Southey, Graham G Giles, Roger L Milne
AMERICAN JOURNAL OF CLINICAL NUTRITION | OXFORD UNIV PRESS | Published : 2018
Background: Folate and other one-carbon metabolism nutrients are essential to enable DNA methylation to occur, but the extent to which their dietary intake influences methylation in adulthood is unclear. Objective: We assessed associations between dietary intake of these nutrients and DNA methylation in peripheral blood, overall and at specific genomic locations. Design: We conducted a cross-sectional study using baseline data and samples from 5186 adult participants in the Melbourne Collaborative Cohort Study (MCCS). Nutrient intake was estimated from a food-frequency questionnaire. DNA methylation was measured by using the Illumina Infinium HumanMethylation450 BeadChip array (HM450K). We a..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
Supported by the Australian National Health and Medical Research Council (NHMRC; grant 1088405). Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by the NHMRC (grants 396414 and 209057) and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC (grants 1011618, 1026892, 1027505, 1050198, 1043616, and 1074383). MCS is an NHMRC Senior Research Fellow (1061177). DDB is a University of Melbourne Research at Melbourne Accelerator Program (R@MAP) Senior Research Fellow and NHMRC RD Wright Career Development Fellow. The funding bodies had no role in the study design, data collection or analysis, decision to publish, or preparation of the manuscript.