Journal article

NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults

Fahad M Aldakheel, Jane E Bourke, Paul S Thomas, Melanie C Matheson, Michael J Abramson, Garun S Hamilton, Caroline J Lodge, BruceR Thompson, E Haydn Walters, Katrina J Allen, Bircan Erbas, Jennifer L Perret, Shyamali C Dharmage, Adrian J Lowe



BACKGROUND: Asthma and allergic diseases are heterogeneous. Measurement of biomarkers in exhaled breath condensate (EBC) may help to discriminate between different phenotypes and may assist with clinical prognostication. OBJECTIVES: We aimed to assess associations between total nitric oxide products (NOx ) in EBC and different allergic phenotypes and lung function in young and middle-aged adults. METHODS: Cross-sectional analyses were nested within two Australian longitudinal studies, the Melbourne Atopy Cohort Study (MACS, mean age 17.8 years) and the Tasmanian Longitudinal Health Study (TAHS, mean age 49.4 years). Levels of EBC NOx were determined by Griess-reaction fluorescent method. Ass..

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Awarded by NHMRC of Australia

Funding Acknowledgements

F.M.A is supported by the Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University (Riyadh - Saudi Arabia). S.C.D, A.J.L, P.S.T, M.C.M and C.J.L are supported by the National Health and Medical Research Council (NHMRC). J.E.B supported by Monash University. Both MACS and TAHS cohorts are supported by grants from the NHMRC of Australia (MACS grant #APP454856; TAHS grants #299901, #454425, #566931, #628513 and #1021275). The first 6 years of MACS was funded by Nestec, a subsidiary of Nestle Australia. The authors have an equipment grant from the University of Melbourne (Melbourne, Australia).