Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration
Rose Tan, Robyn H Guymer, Chi D Luu
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2018
Purpose: To compare static rod function obtained with and without photobleach in control and intermediate age-related macular degeneration (iAMD) participants with and without subretinal drusenoid deposits (SDD). Methods: In this cross-sectional study, retinal sensitivities within the central 24° retina were obtained twice using a dark-adapted chromatic perimeter, both with 505- and 625-nm stimuli. Tests were performed after 30 minutes of dark-adaptation either with or without a preceding photobleach. Multimodal imaging was performed to grade AMD and SDD status, and other retinal changes considered being risk factors for progression to late AMD. The sensitivity difference between both stimul..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) Fellowship
Supported by grants from Ryan Initiative for Macular Research, Macular Disease Foundation Australia, Australia Awards Scholarship (RT; Canberra, Australian Capital Territory, Australia), National Health and Medical Research Council (NHMRC) Fellowship (#1103013, RHG; Canberra, Australian Capital Territory, Australia). The Centre for Eye Research Australia (CERA; East Melbourne, Victoria, Australia) receives Operational Infrastructure Support from the Victorian Government.