PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold
Bruno Madio, Steve Peigneur, Yanni KY Chin, Brett R Hamilton, Sonia Troeira Henriques, Jennifer J Smith, Ben Cristofori-Armstrong, Zoltan Dekan, Berin A Boughton, Paul F Alewood, Jan Tytgat, Glenn F King, Eivind AB Undheim
Cellular and Molecular Life Sciences | SPRINGER BASEL AG | Published : 2018
Awarded by Australian Research Council
Awarded by National Health & Medical Research Council
This work was supported by the Brazilian Government (Science Without Borders PhD scholarship to BM), Australian Research Council (DECRA Fellowship DE160101142 to EABU, Future Fellowship FT150100398 to STH, ARC Linkage Grant LP140100832 to BRH and GFK), and National Health & Medical Research Council (Principal Research Fellowship APP1044414 to GFK). We thank Jason Cockington and Gillian Lawrence for maintenance of sea anemones, and Dr. Alun Jones for help with mass spectrometry experiments. Antimicrobial screens were performed by CO-ADD, funded by the Wellcome Trust (UK) and The University of Queensland (Australia). We thank Dr. Lachlan Rash for assistance with ASIC clone acquisition; Prof. John Wood for ASIC1a, ASIC2a, and ASIC3 clones; Prof. Stefan Grunder for the ASIC1b clone; Prof. Alan Goldin for the -Na<INF>V</INF>1.6 clone; and Prof. Frank Bosmans for the -Na<INF>V</INF>1.7 clone.