Journal article
Biochemical diagnosis of chromaffin cell tumors in patients at high and low risk of disease: plasma versus urinary free or deconjugated o-methylated catecholamine metabolites
G Eisenhofer, A Prejbisz, M Peitzsch, C Pamporaki, J Masjkur, N Rogowski-Lehmann, K Langton, E Tsourdi, M Peczkowska, S Fliedner, T Deutschbein, F Megerle, HJLM Timmers, R Sinnott, F Beuschlein, M Fassnacht, A Januszewicz, JWM Lenders
Clinical Chemistry | AMER ASSOC CLINICAL CHEMISTRY | Published : 2018
Abstract
BACKGROUND: Measurements of plasma or urinary metanephrines are recommended for diagnosis of pheochromocytoma and paraganglioma (PPGL). What test offers optimal diagnostic accuracy for patients at high and low risk of disease, whether urinary free metanephrines offer advantages over deconjugated metanephrines, and what advantages are offered by including methoxytyramine in panels all remain unclear. METHODS: A population of 2056 patients with suspected PPGLs underwent prospective screening for disease using mass spectrometric-based measurements of plasma free, urinary deconjugated, and urinary free metanephrines and methoxytyramine. PPGLs were confirmed in 236 patients and were excluded in o..
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Awarded by Seventh Framework Programme
Funding Acknowledgements
Deutsche Forschungsgemeinschaft (CRC/Transregio 205/1), Entity: European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement 259735, European Union Horizon 2020 Program (ENS@T-HT - #633983-2), Institute of Cardiology. G. Eisenhofer, Deutsche Forschungsgemeinschaft (EI855/1/2, KFO252).