Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak; Michael JG Milevskiy; Rachel M Joyce; Johanna F Dekkers; Paul R Jamieson; Bhupinder Pal; Caleb A Dawson; Yifang Hu; Stuart H Orkin; Warren S Alexander; Geoffrey J Lindeman; Gordon K Smyth; Jane E Visvader

Journal article

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

PLOS Biology | PUBLIC LIBRARY SCIENCE | Published : 2018

DOI: 10.1371/journal.pbio.2004986

University of Melbourne Researchers

Michael Milevskiy Author Medical Biology (W.E.H.I.)

Ewa Michalak Author The Sir Peter MacCallum Department of Oncology

Jane Visvader Author Medical Biology (W.E.H.I.)

Geoffrey Lindeman Author Medicine - Royal Melbourne Hospital

Bhupinder Pal Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

National Health and Medical Research Council https://www.nhmrc.gov.au/ (grant numbers 1016701, 1024852, 1086727, 1054618, 1113577); IRIISS; Senior Principal Research Fellowships (grant numbers 1058344, 1078730, 1058892, 1102742 held by WSA, GJL, GKS, and JEV, respectively). Operational Infrastructure Support from the Victorian State Government (VCA). Australian Cancer Research Foundation https://www.acrf.com.au/. National Breast Cancer Foundation https://nbcf.org.au/ (grant number ECF-15-002). Career Development Fellowship held by EMM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.