Functions of the CXC ligand family in the pancreatic tumor microenvironment
Nien-Hung Lee, Mehrdad Nikfarjam, Hong He
PANCREATOLOGY | ELSEVIER SCIENCE BV | Published : 2018
Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies. This review highlights the roles of selected CXCLs in the interactions between pancreatic tumor and its stroma, and in CSC phenotypes, which..View full abstract
The authors would like to acknowledge Pancare Foundation (www.pancare.org.au) for supporting the pancreatic cancer research program in the Department of Surgery.