Journal article

The implementation of Xpert MTB/RIF assay for diagnosis of tuberculosis in Nepal: A mixed-methods analysis

Basant Joshi, Trisasi Lestari, Stephen Michael Graham, Sushil Chandra Baral, Sharat Chandra Verma, Gokarna Ghimire, Bandana Bhatta, Shyam Prakash Dumre, Adi Utarini



BACKGROUND: Tuberculosis (TB) is a major public health problem in low and middle-income countries. Early detection and enrolment of TB cases is a challenge for National TB Programs. OBJECTIVE: To understand the performance and feasibility for scale-up of Xpert MTB/RIF assay for the TB diagnosis in Nepal. DESIGN: Implementation research employed mixed-method sequential explanatory design. The results of Xpert MTB/RIF assay were analysed in 26 TB diagnostic centres where Xpert machines had been installed before 2015. In-depth interviews and focus group discussions were conducted with stakeholders, purposively selected to represent experiences in centres that were functioning well, poorly or no..

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Funding Acknowledgements

This research was a part of postgraduate thesis. The scholarship for this degree was funded by the Special Programme for Research and Training in Tropical Diseases at the World Health Organization (WHO/TDR) and Universitas Gadjah Mada, Indonesia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.We would like to express our gratitude to WHO/TDR, Universitas Gadjah Mada, Indonesia for providing scholarship for Postgraduate study in implementation research on tropical diseases. We would also like to thank Nepal NTP, District Health/Public Health Office for providing support during the research. We are also thankful to all the participants for their active participation in this research.