Understanding Interventional Effects: A More Natural Approach to Mediation Analysis?
Margarita Moreno-Betancur, John B Carlin
EPIDEMIOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
The causal mediation literature has mainly focused on "natural effects" as measures of mediation, but these have been criticized for their reliance on empirically unverifiable assumptions. They are also impossible to estimate without additional untestable assumptions in the common situation of exposure-induced mediator-outcome confounding. "Interventional effects" have been proposed as alternative measures that overcome these limitations, and 2 versions have been described for the exposure-induced confounding problem. We aim to provide insight into the interpretation of these effects, particularly by describing randomized controlled trials that could hypothetically be conducted to estimate t..View full abstract
Awarded by Centre of Research Excellence grant from the Australian National Health & Medical Research Council
Supported by a Centre of Research Excellence grant from the Australian National Health & Medical Research Council, ID#1035261, to the Victorian Centre for Biostatistics (ViCBiostat). The Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.