Journal article
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen
HY Lim, SY Lim, CK Tan, CH Thiam, CC Goh, D Carbajo, SHS Chew, P See, S Chakarov, XN Wang, LH Lim, LA Johnson, J Lum, CY Fong, A Bongso, A Biswas, C Goh, M Evrard, KP Yeo, R Basu Show all
Immunity | Published : 2018
Abstract
The maintenance of appropriate arterial tone is critically important for normal physiological arterial function. However, the cellular and molecular mechanisms remain poorly defined. Here, we have shown that in the mouse aorta, resident macrophages prevented arterial stiffness and collagen deposition in the steady state. Using phenotyping, transcriptional profiling, and targeted deletion of Csf1r, we have demonstrated that these macrophages—which are a feature of blood vessels invested with smooth muscle cells (SMCs) in both mouse and human tissues—expressed the hyaluronan (HA) receptor LYVE-l. Furthermore, we have shown they possessed the unique ability to modulate collagen expression in SM..
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Awarded by National Research Foundation
Funding Acknowledgements
We thank K. Shortman for critical discussion, Y.H. Lee, Y.S. Yip, and Y.L. Chua for technical assistance, and G.H. Teo and P.E. Hutchinson from Flow Cytometry Lab and E. Koh from Advanced Imaging core facility (Life Science Institute, Immunology programme, NUS) for sharing their expertise. This work was supported by NMRC (CBRGnov094) and NRF grants to V.A., UK Medical research Council funding to D.G.J., and EMBO YIP, SIgN core funding, and Singapore NRF Senior Investigatorship (NRFI2017-02) to F.G.