CSF-1 in Inflammatory and Arthritic Pain Development
Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2018
Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, also known as M-CSF, acts via its receptor (CSF-1R, c-Fms) to regulate the development of the monocyte/macrophage lineage and to act locally in tissues to control macrophage numbers and function. It has been implicated in the control of neuropathic pain via a central action on microglia. We report in this study that systemic administration of a neutralizing anti-CSF-1R or CSF-1 mAb inhibits the development of inflammatory pain induced by zymosan, GM-CSF, and TNF in mice. This approach also prevented but did not ameliorate the development of arthritic pain and opti..View full abstract
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Awarded by Deutsche Forschungsgemeinschaft
This work was supported by a grant (1043147) and J.A.H. was supported by a Senior Principal Research Fellowship from the National Health and Medical Research Council of Australia. I.F. was supported by a grant from the Deutsche Forschungsgemeinschaft (IRTG 2168).