Within-host modeling of blood-stage malaria

David S Khoury; Rosemary Aogo; Georges Randriafanomezantsoa-Radohery; James M McCaw; Julie A Simpson; James S McCarthy; Ashraful Haque; Deborah Cromer; Miles P Davenport

Journal article

Within-host modeling of blood-stage malaria

David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport

IMMUNOLOGICAL REVIEWS | WILEY | Published : 2018

DOI: 10.1111/imr.12697

Abstract

Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmodium falciparum, is increasing in South East Asia. Control measures including novel drugs and vaccines are in development, and contributions to the rational design and optimal usage of these interventions are urgently needed. Infection involves the complex interaction of parasite dynamics, host immunity, and drug effects. The long life cycle (48 hours in the common human species) and synchronized replication cycle of the parasite population present significant challenges to modeling the dynamics of Plasmodium infection. Coupled with these, variation in immune reco..

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University of Melbourne Researchers

James McCaw Author Mathematics and Statistics

Julie Simpson Author Melbourne School of Population and Global Health

Ashraful Haque Author Microbiology and Immunology

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Grants

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council (NHMRC), Australia

Funding Acknowledgements

Australian Research Council, Grant/Award Number: DP120100064, DP180103875, DP170103076 and FT110100250; National Health and Medical Research Council (NH&MRC), Australia, Grant/Award Number: 1082022, 1141921, 1080001, 1028634, 1100394, 1104975, 1028641, 1126399 and 1134989; International Postgraduate Research Scholarship; Scientia PhD Scholarship