Journal article

Sympathoexcitation following intermittent hypoxia in rat is mediated by circulating angiotensin II acting at the carotid body and subfornical organ

Seung Jae Kim, Angelina Y Fong, Paul M Pilowsky, Stephen BG Abbott

The Journal of Physiology | WILEY | Published : 2018

Abstract

KEY POINTS: In anaesthetized rats, acute intermittent hypoxia increases sympathetic nerve activity, sympathetic peripheral chemoreflex sensitivity and central sympathetic-respiratory coupling. Renin-angiotensin system inhibition prevents the sympathetic effects of intermittent hypoxia, with intermittent injections of angiotensin II into the systemic circulation replicating these effects. Bilateral carotid body denervation reduces the sympathetic effects of acute intermittent hypoxia and eliminates the increases in chemoreflex sensitivity and sympathetic-respiratory coupling. Pharmacological inhibition of the subfornical organ also reduces the sympathetic effects of acute intermittent hypoxia..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia Fellowship


Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Postgraduate Award from the Australian Government


Funding Acknowledgements

Work in the authors' laboratory is supported by the National Health and Medical Research Council of Australia Fellowship (PMP; 1024489) (NHMRC Project Grants: 1065485, 1082215) and the Heart Research Institute. SBGA is supported by the National Health and Medical Research Council of Australia (Grant GNT1052674) and the University of Sydney. SJK is supported by an Australian Postgraduate Award (APA SC0042) from the Australian Government and awarded by the University of Sydney, as well as a Heart Research Institute scholarship.