Sympathoexcitation following intermittent hypoxia in rat is mediated by circulating angiotensin II acting at the carotid body and subfornical organ
Seung Jae Kim, Angelina Y Fong, Paul M Pilowsky, Stephen BG Abbott
The Journal of Physiology | WILEY | Published : 2018
KEY POINTS: In anaesthetized rats, acute intermittent hypoxia increases sympathetic nerve activity, sympathetic peripheral chemoreflex sensitivity and central sympathetic-respiratory coupling. Renin-angiotensin system inhibition prevents the sympathetic effects of intermittent hypoxia, with intermittent injections of angiotensin II into the systemic circulation replicating these effects. Bilateral carotid body denervation reduces the sympathetic effects of acute intermittent hypoxia and eliminates the increases in chemoreflex sensitivity and sympathetic-respiratory coupling. Pharmacological inhibition of the subfornical organ also reduces the sympathetic effects of acute intermittent hypoxia..View full abstract
Awarded by National Health and Medical Research Council of Australia Fellowship
Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Postgraduate Award from the Australian Government
Work in the authors' laboratory is supported by the National Health and Medical Research Council of Australia Fellowship (PMP; 1024489) (NHMRC Project Grants: 1065485, 1082215) and the Heart Research Institute. SBGA is supported by the National Health and Medical Research Council of Australia (Grant GNT1052674) and the University of Sydney. SJK is supported by an Australian Postgraduate Award (APA SC0042) from the Australian Government and awarded by the University of Sydney, as well as a Heart Research Institute scholarship.