Genomic Exploration of Within-Host Microevolution Reveals a Distinctive Molecular Signature of Persistent Staphylococcus aureus Bacteraemia
Stefano Giulieri, Sarah Baines, Romain Guerillot, Torsten Semann, Anders Goncalves da Silva, Mark Schultz, Ruth Massey, Natasha Holmes, Timothy Stinear, Benjamin Howden
Genome Medicine | BMC | Published : 2018
Background: Large-scale genomic studies of within-host evolution during Staphylococcus aureus bacteraemia (SAB) are needed to understanding bacterial adaptation underlying persistence and thus refining the role of genomics in management of SAB. However, available comparative genomic studies of sequential SAB isolates have tended to focus on selected cases of unusually prolonged bacteraemia, where secondary antimicrobial resistance has developed. To understand the bacterial genomic evolution during SAB more broadly, we applied whole genome sequencing to a large collection of sequential isolates obtained from patients with persistent or relapsing bacteraemia. Results: We show that, while adapa..View full abstract
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Awarded by National Health and Medical Research Council, Australia
This work was supported by a Research Fellowship to TPS (GNT1008549) and Practitioner Fellowship to BPH (GNT1105905) from the National Health and Medical Research Council, Australia. Doherty Applied Microbial Genomics is funded by the Department of Microbiology and Immunology at The University of Melbourne. SGG was supported by the SICPA Foundation, Lausanne, Switzerland.