Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue
Oneil G Bhalala, Artika P Nath, Michael Inouye, Christopher R Sibley
PLoS Genetics | PUBLIC LIBRARY SCIENCE | Published : 2018
Schizophrenia and the affective disorders, here comprising bipolar disorder and major depressive disorder, are psychiatric illnesses that lead to significant morbidity and mortality worldwide. Whilst understanding of their pathobiology remains limited, large case-control studies have recently identified single nucleotide polymorphisms (SNPs) associated with these disorders. However, discerning the functional effects of these SNPs has been difficult as the associated causal genes are unknown. Here we evaluated whether schizophrenia and affective disorder associated-SNPs are correlated with gene expression within human brain tissue. Specifically, to identify expression quantitative trait loci ..View full abstract
Awarded by Australian Heart Foundation
APN was supported by the Australian Postgraduate Award and an International Postgraduate Research Scholarship from The University of Melbourne. MI is supported by an NHMRC and Australian Heart Foundation Career Development Fellowship (no. 1061435). CRS is supported by a fellowship from the Edmond J. Safra Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.