Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits
Alexandria K Driessen, Michael J Farrell, Mathias Dutschmann, Davor Stanic, Alice E McGovern, Stuart B Mazzone
BRAIN STRUCTURE & FUNCTION | SPRINGER HEIDELBERG | Published : 2018
Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to the poorly studied medullary paratrigeminal nucleus. In the present study, we used neuroanatomical tracing, pharmacology and physiology in guinea pig to investigate the paratrigeminal neural circuits mediating jugular ganglia-evoked respiratory reflexes. Retrogradely traced laryngeal jugular ganglia neurons were largely (> 60%) unmyelinated and expressed the neuropeptide substance P and calcitonin gene-related peptide, although a population (~ 30%) of larger diameter myelinated jugular neurons was defined by the expression of vGlut1. Within the brainstem, vagal afferent terminals were confined to the ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was supported by Grants to Dr. SB Mazzone and Dr MJ Farrell from the National Health and Medical Research Council (NHMRC) of Australia .