Journal article
PTHrP, its receptor, and protein kinase A activation in osteosarcoma
CR Walkley, MK Walia, PW Ho, TJ Martin
Molecular and Cellular Oncology | TAYLOR & FRANCIS INC | Published : 2014
Abstract
In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.
Grants
Funding Acknowledgements
Work from the authors' laboratories is supported by the NHMRC (Australia), Cancer Council of Victoria, Zig Inge Foundation, 5 Point Foundation, and by the Victorian State Government Operational Infrastructure Support Program (to St. Vincent's Institute). C.W. is the Philip Desbrow Senior Research Fellow of the Leukaemia Foundation.