Journal article

Schistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota

Timothy P Jenkins, Laura E Peachey, Nadim J Ajami, Andrew S MacDonald, Michael H Hsieh, Paul J Brindley, Cinzia Cantacessi, Gabriel Rinaldi

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2018

Abstract

In spite of the extensive contribution of intestinal pathology to the pathophysiology of schistosomiasis, little is known of the impact of schistosome infection on the composition of the gut microbiota of its mammalian host. Here, we characterised the fluctuations in the composition of the gut microbial flora of the small and large intestine, as well as the changes in abundance of individual microbial species, of mice experimentally infected with Schistosoma mansoni with the goal of identifying microbial taxa with potential roles in the pathophysiology of infection and disease. Bioinformatic analyses of bacterial 16S rRNA gene data revealed an overall reduction in gut microbial alpha diversi..

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University of Melbourne Researchers

Grants

Awarded by NIAID Schistosomiasis Resource Center for distribution through BEI Resources, NIH-NIAID Contract


Awarded by NIAID, National Institutes of Health


Funding Acknowledgements

T.P.J. is the grateful recipient of a PhD scholarship by the Biotechnology and Biological Sciences Research Council (BBSRC) of the United Kingdom. The authors would like to thank Drs Hong-Bin Yan and Rafael Nacif-Pimenta for technical assistance during sample collection. Experimentally infected mice and uninfected controls were provided by the NIAID Schistosomiasis Resource Center for distribution through BEI Resources, NIH-NIAID Contract HHSN272201000005I. This study was partially supported by awards R01AI072773 (PJB) and R21AI109532 (GR) from NIAID, National Institutes of Health.