Journal article

Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat

Angela Juhasz, Tatiana Belova, Chris G Florides, Csaba Maulis, Iris Fischer, Gyongyver Gell, Zsfia Birinyi, Jamie Ong, Gabriel Keeble-Gagnere, Amudha Maharajan, Wujun Ma, Peter Gibson, Jizeng Jia, Daniel Lang, Klaus FX Mayer, Manuel Spannagl, Jason A Tye-Din, Rudi Appels, Odd-Arne Olsen

SCIENCE ADVANCES | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2018

Abstract

Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker's asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation..

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Grants

Awarded by Norwegian Research Council (NFR)


Awarded by Australian Government Department of Industry, Innovation, Science, Research and Tertiary Education


Awarded by Grain Research Development Corporation


Awarded by Hungarian National Research Fund


Awarded by European Social Fund


Funding Acknowledgements

We thank Graminor AS and the Norwegian Research Council (NFR) for financial support for NFR project 199387; Australian Government Department of Industry, Innovation, Science, Research and Tertiary Education funding agreement ACSRF00542; and Grain Research Development Corporation agreement UMU00037. G.G. was supported by the Hungarian National Research Fund (OTKA PD 115641). A.J., G.G., and Z.B. also thank the European Union together with the European Social Fund (grant nos. TAMOP-4.2.4.A/2-11/1-2012-0001 and GINOP-2.3.2-15-2016-00028).