Journal article
Accuracy of NEXUS II head injury decision rule in children: A prospective PREDICT cohort study
FE Babl, E Oakley, SR Dalziel, ML Borland, N Phillips, A Kochar, S Dalton, JA Cheek, Y Gilhotra, J Furyk, J Neutze, S Donath, S Hearps, LM Crowe, M Arpone, S Bressan, MD Lyttle
Emergency Medicine Journal | BMJ PUBLISHING GROUP | Published : 2019
Abstract
Objective The National Emergency X-Radiography Utilisation Study II (NEXUS II) clinical decision rule (CDR) can be used to optimise the use of CT in children with head trauma. We set out to externally validate this CDR in a large cohort. Methods We performed a prospective observational study of patients aged <18 years presenting with head trauma of any severity to 10 Australian/New Zealand EDs. In a planned secondary analysis, we assessed the accuracy of the NEXUS II CDR (with 95% CI) to detect clinically important intracranial injury (ICI). We also assessed clinician accuracy without the rule. Results Of 20 137 total patients, we excluded 28 with suspected penetrating injury. Median age was..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The study was funded by grants from the National Health and Medical Research Council (project grant GNT1046727, Centre of Research Excellence for Paediatric Emergency Medicine GNT1058560), Canberra, Australia; the Murdoch Childrens Research Institute, Melbourne, Australia; the Emergency Medicine Foundation (EMPJ-11162), Brisbane, Australia; Perpetual Philanthropic Services (2012/1140), Australia; Auckland Medical Research Foundation (No. 3112011) and the A + Trust (Auckland District Health Board), Auckland, New Zealand; WA Health Targeted Research Funds 2013, Perth, Australia; the Townsville Hospital and Health Service Private Practice Research and Education Trust Fund, Townsville, Australia and supported by the Victorian Government's Infrastructure Support Program, Melbourne, Australia. FEB's time was part funded by a grant from the Royal Children's Hospital Foundation, Melbourne, Australia, an NHMRC Practitioner Fellowship GNT1124466 and a Melbourne Children's Clinician Scientist Fellowship. SRD's time was part funded by the Health Research Council of New Zealand (HRC13/556).