Journal article

Age dependency of risk factors for cognitive decline

N Legdeur, MW Heymans, HC Comijs, M Huisman, AB Maier, PJ Visser

BMC Geriatrics | BMC | Published : 2018

Abstract

BACKGROUND: Risk factors for cognitive decline might depend on chronological age. The aim of the study was to explore the age dependency of risk factors for cognitive decline in cognitively healthy subjects aged 55-85 years at baseline. METHODS: We included 2527 cognitively healthy subjects from the Longitudinal Aging Study Amsterdam (LASA). Median follow-up was 9.1 (IQR: 3.2-19.0) years. The association of genetic and cardiovascular risk factors, depressive symptoms, inflammation markers and lifestyle risk factors with decline in MMSE and memory function was tested using spline regression analyses. RESULTS: Subjects were on average 70.1 (SD 8.8) years old at baseline. Based on a spline regr..

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Grants

Awarded by EU/EFPIA Innovative Medicines Initiative Joint Undertaking EMIF grant


Funding Acknowledgements

This work has received support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EMIF grant agreement no. 115372. The Longitudinal Aging Study Amsterdam (LASA) is primarily funded by the Dutch Ministry of Health, Welfare and Sports and the VU University Amsterdam.