Journal article

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

Ranja Salvamoser, Kerstin Brinkmann, Lorraine A O'Reilly, Lachlan Whitehead, Andreas Strasser, Marco J Herold

CELL DEATH AND DIFFERENTIATION | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Caspases exert critical functions in diverse cell death pathways, including apoptosis and pyroptosis, but some caspases also have roles in the processing of cytokines into their functional forms during inflammation. The roles of many caspases have been unravelled by the generation of knockout mice, but still very little is known about the overlapping functions of caspases as only a few studies report on double or triple caspase knockout mice. For example, the functions of caspase-12 in cell death and inflammation, on its own or overlapping with the functions of caspase-1 and caspase-11, are only poorly understood. Therefore, we generated a novel mutant mouse strain lacking all three inflamma..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Leukaemia and Lymphoma Society of America


Awarded by Cancer Council of Victoria


Awarded by Australian Government Independent Research Institute Infrastructure Support Scheme


Funding Acknowledgements

We thank T Ballinger, S Russo, G Siciliano, C Stivala. and S Stoev for their help with experiments with mice; S Monard and his team for their help with flow cytometry. Our work is supported by the Australian National Health and Medical Research Council (Project Grant 1145728 to MJH and 1143105 to MJH and AS; Programme Grant 1016701 to AS and Fellowship 1020363 to AS), the Leukaemia and Lymphoma Society of America (LLS SCOR 7001-13 to AS and MJH), the Cancer Council of Victoria (1052309 to AS and Venture Grant MJH and AS) and by operational infrastructure grants through the Australian Government Independent Research Institute Infrastructure Support Scheme (9000220) and the Victorian State Government Operational Infrastructure Support Program.