Journal article

Protecting against electrode insertion trauma using dexamethasone.

Scott Chambers, Carrie Newbold, Dimitra Stathopoulos, Karina Needham, Chris Miller, Frank Risi, Ya Lang Enke, Godofredo Timbol, Robert Cowan

Cochlear Implants Int | Published : 2019

Abstract

OBJECTIVE: To compare the benefits of a dexamethasone-eluting array for hearing preservation and cochlear histopathology in low trauma (soft-surgery) and high trauma models of cochlear implant surgery. METHODS: Adult guinea pigs were implanted with an intra-cochlear array using two different surgical procedures: either a soft-surgery approach or following generation of electrode insertion trauma (high trauma). Two methods of dexamethasone delivery were evaluated: elution from an electrode array alone, and elution from a cochlear implant electrode array in combination with a pre-operative systemic injection. All electrode arrays were implanted for a period of 4 weeks. Outcome measures at 4 we..

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