Journal article

Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

Quinn A Besford, Yi Ju, Ting-Yi Wang, Gyeongwon Yun, PavelV Cherepanov, Christoph E Hagemeyer, Francesca Cavalieri, Frank Caruso

SMALL | WILEY-V C H VERLAG GMBH | Published : 2018

Abstract

Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for imaging and drug delivery. Herein, the interfacial self-assembly of pH-responsive metal-phenolic networks (MPNs) on the liquid-liquid interface of oil-in-water emulsions is reported. Oleic acid emulsions of 100-250 nm in diameter are generated by ultrasonication, to which poly(ethylene glycol) (PEG)-based polyphenolic ligands are assembled with simultaneous crosslinking by metal ions, thus forming an interfacial MPN. PEG provides a protective barrier on the emulsion phase and renders the emulsion low fouling. The MPN-coated emulsions have a similar size and dispe..

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC


Awarded by National Health and Medical Research Council Senior Principal Research Fellowship


Funding Acknowledgements

This work was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). This research was also supported by the ARC under the Future Fellowship scheme (F. Cavalieri, FT140100873). F. Caruso acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (APP1135806). The authors acknowledge the Bio21 Advanced Microscopy facility and the Bioscience Microscopy Unit at The University of Melbourne. The authors thank Dr. Tim Ryan for useful discussions and Paul Brannon for assistance with the microscopy analyses.