Journal article

Antibacterial activity of rhodomyrtone on Clostridium difficile vegetative cells and spores in vitro

Sutthirat Srisuwan, Kate E Mackin, Dianna Hocking, Dena Lyras, Vicki Bennett-Wood, Supayang P Voravuthikunchai, Roy M Robins-Browne

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | ELSEVIER | Published : 2018

Abstract

The increasing incidence and severity of diarrhoea and colitis caused by Clostridium difficile, together with a high rate of relapse following treatment with currently recommended antimicrobials, calls for novel interventions for C. difficile infection (CDI). Rhodomyrtone, a bioactive compound derived from the leaves of the rose myrtle (Rhodomyrtus tomentosa) has demonstrated antibacterial activity against several Gram-positive bacteria. This study compared the in vitro antimicrobial activity of rhodomyrtone on C. difficile with that of vancomycin, a recommended agent for the treatment of CDI. Determination of the minimum inhibitory concentrations (MICs) and minimum bactericidal concentratio..

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