Journal article

Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

Kieran M Short, Alexander N Combes, Valerie Lisnyak, James G Lefevre, Lynelle K Jones, Melissa H Little, Nicholas A Hamilton, Ian M Smyth

eLife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2018

Abstract

Branching morphogenesis of the ureteric bud is integral to kidney development; establishing the collecting ducts of the adult organ and driving organ expansion via peripheral interactions with nephron progenitor cells. A recent study suggested that termination of tip branching within the developing kidney involved stochastic exhaustion in response to nephron formation, with such a termination event representing a unifying developmental process evident in many organs. To examine this possibility, we have profiled the impact of nephron formation and maturation on elaboration of the ureteric bud during mouse kidney development. We find a distinct absence of random branch termination events with..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Awarded by Human Frontier Science Program


Funding Acknowledgements

National Health and Medical Research Council 1002748 Melissa H. LittleAustralian Research Council DP160103100 Nicholas A. Hamilton Ian M. SmythHuman Frontier Science Program RGP0039/2011 Melissa H. Little Ian M. SmythNational Health and Medical Research Council 1063696 Melissa H. LittleThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.