Journal article

Glucocorticoid-Induced Insulin Resistance in Men Is Associated With Suppressed Undercarboxylated Osteocalcin

Lewan Parker, Xuzhu Lin, Andrew Garnham, Glenn McConell, Nigel K Stepto, David L Hare, Elizabeth Byrnes, Peter R Ebeling, Ego Seeman, Tara C Brennan-Speranza, Itamar Levinger

JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 2019

Abstract

In mice, glucocorticoid-induced insulin resistance occurs largely through impaired osteoblast function and decreased circulating undercarboxylated osteocalcin (ucOC). Whether these mechanisms contribute to glucocorticoid-induced insulin resistance in humans has yet to be established. In addition, the effects of glucocorticoids on the exercise-induced increase in circulating ucOC and insulin sensitivity are also unknown. We hypothesized that acute glucocorticoid treatment would lead to basal and postexercise insulin resistance in part through decreased circulating ucOC and ucOC-mediated skeletal muscle protein signaling. Nine healthy men completed two separate cycling sessions 12 hours after ..

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Grants

Awarded by Future Leader Fellowship from the National Heart Foundation of Australia


Funding Acknowledgements

This study was funded by Victoria University. A/Prof Levinger was supported by a Future Leader Fellowship (ID: 100040) from the National Heart Foundation of Australia. Dr Parker was supported by an Alfred Deakin Postdoctoral Fellowship from Deakin University. Dr Brennan-Speranza was supported by an NHMRC Early Career Fellowship. A/Prof Nigel Stepto was supported by the Australian Governments Collaborative Research Network.