Patient-reported outcomes are worse for progressive-onset multiple sclerosis than relapse-onset multiple sclerosis, particularly early in the disease process
Y Zhang, BV Taylor, S Simpson, L Blizzard, I van der Mei
EUROPEAN JOURNAL OF NEUROLOGY | WILEY | Published : 2019
BACKGROUND AND PURPOSE: Treatments for progressive-onset multiple sclerosis (MS) are lacking. To improve the disease management for progressive-onset MS, the differences between relapse-onset MS and progressive-onset MS in patient-reported disability, progression and symptoms were examined. METHODS: A total of 1985 participants of the Australian Multiple Sclerosis Longitudinal Study were included. Associations between onset type and outcomes were assessed with negative binomial regression. RESULTS: The severity of 17 of the 19 outcomes was significantly higher for progressive-onset MS patients than relapse-onset MS patients, including perspectives from disability, progression over the last y..View full abstract
This study was funded by MS Research Australia. All participants of the Australian MS Longitudinal Study are sincerely thanked for their support and willingness to complete surveys.