Journal article

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D Brady, Pablo M Casillas-Espinosa, Denes V Agoston, Edward H Bertram, Alaa Kamnaksh, Bridgette D Semple, Sandy R Shultz

NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as they allow for the rigorous investigation into the causal relationship between TBI and PTE, the pathophysiological mechanisms of PTE, the validation and implementation of PTE biomarkers, and the assessment of PTE treatments, in a tightly controlled, time- and cost-efficient manner in experimental subjects known to be experiencing epileptogenic processes. This artic..

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Grants

Awarded by National Institutes of Health - Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

The authors acknowledge funding from the National Institutes of Health - Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx; U54 NS100064) project; the National Health and Medical Research Council of Australia (NHMRC).