Journal article

New insights into the timing and potential mechanisms of respiratory-induced cortical arousals in obstructive sleep apnea

Jason Amatoury, Amy S Jordan, Barbara Toson, Nguyen Chinh, Andrew Wellman, Danny J Eckert

SLEEP | OXFORD UNIV PRESS INC | Published : 2018

Abstract

Study Objectives: A negative intrathoracic pressure threshold is one commonly proposed mechanism for triggering respiratory-induced arousals in obstructive sleep apnea (OSA). If so, they should occur during inspiration, shortly after maximal negative pressure swings. Alternatively, respiratory-induced arousals may occur throughout the respiratory cycle if other mechanisms also contribute. However, arousal timing has been minimally investigated. This study aimed to (1) determine the temporal relationship between respiratory-induced arousals and breathing phase and (2) characterize neuromuscular and load compensation responses prior to arousal. Methods: Fifty-one CPAP-treated OSA patients unde..

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Grants

Awarded by NeuroSleep, a National Health and Medical Research Council of Australia (NHMRC) Centre of Research Excellence (CRE)


Awarded by National Institutes of Health grant


Awarded by NeuroSleep NHMRC CRE Postdoctoral Fellowship


Awarded by NHMRC Research Fellowship


Funding Acknowledgements

This work was supported by NeuroSleep, a National Health and Medical Research Council of Australia (NHMRC) Centre of Research Excellence (CRE) (1060992) and a National Institutes of Health grant (5R01HL048531). J.A. is supported by a NeuroSleep NHMRC CRE Postdoctoral Fellowship (1060992). D.J.E. is supported by a NHMRC Research Fellowship (1116942).