Journal article
Projection of Long-Term Visual Acuity Outcomes Based on Initial Treatment Response in Neovascular Age-Related Macular Degeneration
V Nguyen, V Daien, R Guymer, S Young, A Hunyor, S Fraser-Bell, A Hunt, MC Gillies, D Barthelmes
Ophthalmology | ELSEVIER SCIENCE INC | Published : 2019
Abstract
Purpose: To explore various methods for assessing the early response to vascular endothelial growth factor (VEGF) inhibitors for neovascular age-related macular degeneration and investigate their association with 3-year visual acuity (VA) outcomes. Design: Database study, prospectively designed. Participants: Treatment-naïve eyes in the Fight Retinal Blindness! registry that commenced anti-VEGF therapy between January 1, 2007, and March 1, 2014, that received 3 anti-VEGF injections within the first 3 months. Methods: The early response was defined as occurring up until the fourth injection. Various early response metrics were explored: (1) achieving good VA (≥70 letters; Snellen equivalent, ..
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Funding Acknowledgements
Supported by the Royal Australian New Zealand College of Ophthalmologists Eye Foundation (2007e2009); the National Health and Medical Research Council (NHMRC), Australia (2010e2012; M.C.G., R.G.); the Macular Disease Foundation, Australia (M.C.G.); the Sydney Medical Foundation; the Walter and Gertrud Siegenthaler Foundation, Zurich, Switzerland (D.B.); the Swiss National Foundation (D.B.); and the French Society of Ophthalmology (V.D.). These supporting organizations had no role in the design or conduct of the research.