Journal article

Role of IL-6/RORC/IL-22 axis in driving Th17 pathway mediated immunopathogenesis of schizophrenia

Manjula Subbanna, Venkataram Shivakumar, Pinku Mani Talukdar, Janardhanan C Narayanaswamy, Deepthi Venugopal, Michael Berk, Shivarama Varambally, Ganesan Venkatasubrarnanian, Monojit Debnath

CYTOKINE | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018

Abstract

The immuno-inflammatory origin of schizophrenia in a subset of patients is viewed as a key element of an overarching etiological construct. Despite substantial research, the immune components exerting major effect are yet to be fully clarified. Disrupted T cell networks have consistently been linked to the pathogenesis of schizophrenia. Amongst the Th cell subsets, the Th17 cells have emerged as a paradigmatic lineage with significant functional implications in a vast number of immune mediated diseases including brain disorders such as schizophrenia. The present study was aimed at examining the functional role of the Th17 pathway in schizophrenia. To address this, genotyping of IL17A (rs2275..

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University of Melbourne Researchers

Grants

Awarded by NHMRC


Awarded by Wellcome Trust-DBT India Alliance Intermediate Clinical Fellowship


Awarded by Indian Council of Medical Research


Funding Acknowledgements

MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). SV is the recipient of a current Wellcome Trust-DBT India Alliance Intermediate Clinical Fellowship (Grant number IA/CPHI/15/1/502026). VS is supported by the Indian Council of Medical Research (DHR/HRD/Young Scientist/Type-VI-(2)/2015). MS is supported by UGC-RGNF.