Dendritic cell subsets
Christophe Macri, Ee Shan Pang, Timothy Patton, Meredith O'Keeffe
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018
Dendritic cells (DC) are professional antigen presenting cells comprising a variety of subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the steady state DC continually process and present antigens on MHCI and MHCII, processes that are highly upregulated upon activation. By expressing differential sets of pattern recognition receptors different DC subsets are able to respond to a range of pathogenic and danger stimuli, enabling functional specialisation of the DC. The knowledge of functional specialisation of DC subsets is key to efficient priming of T cells, to the design of effective vaccine adjuvants and to understanding the role of different DC in he..View full abstract
Awarded by NHMRC
Awarded by Worldwide Cancer Research
MOK is supported by an NHMRC Senior Research Fellowship 1077633, NHMRC Project grants 1085934; 1002903 and Worldwide Cancer Research Grant 14-0281. ESP and TP are supported by Australian Postgraduate Awards.