Seizure control and treatment in pregnancy: Observations from the EURAP epilepsy pregnancy registry

T Tomson; D Battino; E Bonizzoni; J Craig; D Lindhout; E Perucca; A Sabers; F Vajda; MJ Brodie; B Schmidt; F Faravelli; R Finnell; S Messina; B Moche; S Ratti; A Erba; D Giavoni; L Prato; S Kochen; G Luef; K Ten Berg; A De Marinis; D Vitezic; J Zarubova; R Kuba; M Dahl; R Kälviäinen; M Beaussart; L Sturua; O Toidze; B Schmitz; P Kwan; G Barcs; SV Thomas; M Neufeld; D Mamoli; M Tanaka; R Mameniskiene; G Kiteva-Trencevska; KO Nakken; W Liao; J Jedrzejczak; A Guekht; O Lokshina; A Russell; D Sokic; V Safcak; B Cebular; MM Ferri; H Baier; B Tettenborn; CW Lai; Özkara; G Escaray; C Baumgartner; M Feichtinger; M Graf; M Hamberger; M Nagler; A Hitchcock; J Graham; R Beran; S Berkovic; A Black; M Cook; J Dunne; N Lawn; P Silbert; C Kilpatrick; T O’brien; C Lander; D McLaughlin; E Somerville; P Boon; K Vonck; C Asmad; D Sepic-Grahovac; M Brázdil; I Novotná; I Tyrlíková; H Krijtova; I Nemcova; D Tislerova; H Vacovska; J Alving; V Stubbings; J Arentsen; J Tørring; B A’ Rogvi Hansen; G Gulliksen; B Pedersen; P Sidenius; T Sørensen; M Worm; S Rainesalo; R Roivanen; A Salmivaara; S Kasradze; I Coban; V Gaus

Journal article

Seizure control and treatment in pregnancy: Observations from the EURAP epilepsy pregnancy registry

T Tomson, D Battino, E Bonizzoni, J Craig, D Lindhout, E Perucca, A Sabers, F Vajda, MJ Brodie, B Schmidt, F Faravelli, R Finnell, S Messina, B Moche, S Ratti, A Erba, D Giavoni, L Prato, S Kochen, G Luef Show all

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

DOI: 10.1212/01.wnl.0000195888.51845.80

Abstract

Objective: To analyze seizure control and treatment in pregnant women with epilepsy. Methods: Seizure control and treatment were recorded prospectively in 1,956 pregnancies of 1,882 women with epilepsy participating in EURAP, an international antiepileptic drugs (AEDs) and pregnancy registry. Results: Of all cases, 58.3% were seizure-free throughout pregnancy. Occurrence of any seizures was associated with localization-related epilepsy (OR: 2.5; 1.7 to 3.9) and polytherapy (OR: 9.0; 5.6 to 14.8) and for tonic-clonic seizures, with oxcarbazepine monotherapy (OR: 5.4; 1.6 to 17.1). Using first trimester as reference, seizure control remained unchanged throughout pregnancy in 63.6%, 92.7% of wh..

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Seizure control and treatment in pregnancy: Observations from the EURAP epilepsy pregnancy registry

Abstract

University of Melbourne Researchers

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