Journal article

Structural variants and selective sweep foci contribute to insecticide resistance in the Drosophila melanogaster genetic reference panel

Paul Battlay, Llewellyn Green, Pontus Leblanc, Joshua Schmidt, Alexandre Fournier-Level, Charles Robin

Published : 2018

Abstract

Patterns of nucleotide polymorphism within populations of Drosophila melanogaster suggest that insecticides have been the selective agents driving the strongest recent bouts of positive selection. However, there is a need to explicitly link selective sweep loci to the particular insecticide phenotypes that could plausibly account for the drastic selective responses that are observed in these non-target insects. Here, we screen the Drosophila Genetic Reference Panel with two common insecticides; malathion (an organophosphate) and permethrin (a pyrethroid). Genome wide association studies map ‘survival-on-malathion’ to two of the largest sweeps in the D. melanogaster genome; Ace and Cyp6g1 . M..

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University of Melbourne Researchers

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