Journal article

Mycobacterium ulceranslow infectious dose and atypical mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer

John Wallace, Kirstie Mangas, Jessica Porter, Renee Marcsisin, Sacha Pidot, Brian Howden, Till Omansen, Weiguang Zeng, Jason Axford, Paul Johnson, Timothy Stinear

Published : 2016

Abstract

Addressing the transmission enigma of the neglected disease Buruli ulcer (BU) is a World Health Organization priority. In Australia, we have observed an association between mosquitoes harboring the causative agent, Mycobacterium ulcerans , and BU. Here we tested a contaminated skin model of BU transmission by dipping the tails from healthy mice in cultures of the causative agent, Mycobacterium ulcerans . Tails were exposed to mosquito ( Aedes notoscriptus and Aedes aegypti ) blood feeding or punctured with sterile needles. Two of 11 of mice with M. ulcerans contaminated tails exposed to feeding A. notoscriptus mosquitoes developed BU. Eighteen of 20 mice subjected to contaminated tail needle..

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