Journal article

Real-time genomic and epidemiological investigation of a multi-institution outbreak of KPC-producing Enterobacteriaceae: a translational study

JC Kwong, C Lane, F Romanes, A Gonçalves da Silva, M Easton, K Cronin, MJ Waters, T Tomita, K Stevens, MB Schultz, SL Baines, NL Sherry, G Carter, A Mu, M Sait, SA Ballard, T Seemann, TP Stinear, BP Howden

Published : 2017


ABSTRACT Background Until recently, KPC-producing Enterobacteriaceae were rarely identified in Australia. Following an increase in the number of incident cases across the state of Victoria, we undertook a real-time combined genomic and epidemiological investigation. The scope of this study included identifying risk factors and routes of transmission, and investigating the utility of genomics to enhance traditional field epidemiology for informing management of established widespread outbreaks. Methods and Findings All KPC-producing Enterobacteriaceae isolates referred to the state reference laboratory from 2012 onwards were included. Whole-genome sequencing (WGS) was performed in parallel wi..

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