Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.

Bao Jian Fan; Xueli Chen; Nisha Sondhi; P Ferdinamarie Sharmila; Nagasamy Soumittra; Sarangapani Sripriya; Srinivasan Sacikala; Rashima Asokan; David S Friedman; Louis R Pasquale; X Raymond Gao; Lingam Vijaya; Jessica Cooke Bailey; Veronique Vitart; Stuart MacGregor; Christopher J Hammond; Chiea Chuen Khor; Jonathan L Haines; Ronnie George; Janey L Wiggs; Mexican American Glaucoma Genetic Study; International Glaucoma Genetics Consortium; and NEIGHBORHOOD Consortium

Journal article

Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.

Bao Jian Fan, Xueli Chen, Nisha Sondhi, P Ferdinamarie Sharmila, Nagasamy Soumittra, Sarangapani Sripriya, Srinivasan Sacikala, Rashima Asokan, David S Friedman, Louis R Pasquale, X Raymond Gao, Lingam Vijaya, Jessica Cooke Bailey, Veronique Vitart, Stuart MacGregor, Christopher J Hammond, Chiea Chuen Khor, Jonathan L Haines, Ronnie George, Janey L Wiggs Show all

Investigative Ophthalmology and Visual Science | Published : 2018

DOI: 10.1167/iovs.17-23536

Download PDF

Abstract

Purpose: To identify genetic risk factors contributing to central corneal thickness (CCT) in individuals from South India, a population with a high prevalence of ocular disorders. Methods: One hundred ninety-five individuals from 15 large South Indian pedigrees were genotyped using the Omni2.5 bead array. Family-based association for CCT was conducted using the score test in MERLIN. Results: Genome-wide association study (GWAS) identified strongest association for single nucleotide polymorphisms (SNPs) in the first intron of WNT7B and CCT (top SNP rs9330813; β = -0.57, 95% confidence interval [CI]: -0.78 to -0.36; P = 1.7 × 10-7). We further investigated rs9330813 in a Latino cohort and four..

View full abstract