Journal article

Whole genome sequence analysis of Salmonella Typhi isolated in Thailand before and after the introduction of a national immunization program

Zoe Dyson, Duy Pham Thanh, Ladaporn Bodhidatta, Carl Jeffries Mason, Apichai Srijan, Maia Rabaa, Phat Voong Vinh, Tuyen Ha Thanh, Guy Thwaites, Stephen Baker, Kathryn Holt

Published : 2016

Abstract

Vaccines against Salmonella Typhi, the causative agent of typhoid fever, are commonly used by travellers, however, there are few examples of national immunization programs in endemic areas. There is therefore a paucity of data on the impact of typhoid immunization programs on localised populations of S . Typhi. Here we have used whole genome sequencing (WGS) to characterise 44 historical bacterial isolates collected before and after a national typhoid immunization program that was implemented in Thailand in 1977 in response to a large outbreak; the program was highly effective in reducing typhoid case numbers. Thai isolates were highly diverse, including 10 distinct phylogenetic lineages or ..

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University of Melbourne Researchers

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