Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery

SE Borisov; L D'Ambrosio; R Centis; S Tiberi; K Dheda; JW Alffenaar; R Amale; E Belilowski; J Bruchfeld; B Canneto; J Denholm; R Duarte; A Esmail; A Filippov; L Davies Forsman; M Gaga; S Ganatra; AI Gaida; B Lazaro Mastrapa; V Manfrin; S Manga; A Maryandyshev; G Massard; P González Montaner; J Mullerpattan; DJ Palmero; A Pontarelli; A Papavasileiou; E Pontali; R Romero Leyet; A Spanevello; ZF Udwadia; P Viggiani; D Visca; G Sotgiu; GB Migliori

Journal article

Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery

SE Borisov, L D'Ambrosio, R Centis, S Tiberi, K Dheda, JW Alffenaar, R Amale, E Belilowski, J Bruchfeld, B Canneto, J Denholm, R Duarte, A Esmail, A Filippov, L Davies Forsman, M Gaga, S Ganatra, AI Gaida, B Lazaro Mastrapa, V Manfrin Show all

Journal of Infection | W B SAUNDERS CO LTD | Published : 2019

DOI: 10.1016/j.jinf.2018.08.003

Abstract

Objectives: No study evaluated the contribution of adjunctive surgery in bedaquiline-treated patients. This study describes treatment outcomes and complications in a cohort of drug-resistant pulmonary tuberculosis (TB) cases treated with bedaquiline-containing regimens undergoing surgery. Methods: This retrospective observational study recruited patients treated for TB in 12 centres in 9 countries between January 2007 and March 2015. Patients who had surgical indications in a bedaquiline-treated programme-based cohort were selected and surgery-related information was collected. Patient characteristics and surgical indications were described together with type of operation, surgical complicat..

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