The developmental lipidome of Haemonchus contortus
Tao Wang, Shuai Nie, Guangxu Ma, Pasi K Korhonen, Anson V Koehler, Ching-Seng Ang, Gavin E Reid, Nicholas A Williamson, Robin B Gasser
INTERNATIONAL JOURNAL FOR PARASITOLOGY | ELSEVIER SCI LTD | Published : 2018
Lipids play crucial roles in the biology of organisms, particularly relating to cellular membranes, energy storage, and intra- or inter-cellular signalling. Despite the recent expansion of the lipidomics field, very little is known about the biology of lipids in metzoan pathogens, and, to date, there has been no global lipidomic study of a parasitic nematode. Using Haemonchus contortus (barber's pole worm) as a model, we describe the first known global lipidome for a parasitic nematode via high throughput LC-MS/MS-based lipidomics. We identified a total of 554 lipid species across four lipid categories, and 18 lipid classes exhibited alterations among six developmental stages (eggs; L3 and e..View full abstract
We would like to thank Haoyun Fang (Department of Biochemistry and Molecular Biology, The University of Melbourne, Australia) for her kind support with lipid extraction. The present study was funded by the Australian Research Council (ARC) and The University of Melbourne. PKK was supported by an Early Career Research Fellowship (ECRF) from The National Health and Medical Research Council of Australia.