Journal article

A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder

David Stacey, K Oliver Schubert, Scott R Clark, Azmeraw T Amare, Elena Milanesi, Carlo Maj, Susan G Leckband, Tatyana Shekhtman, John R Kelsoe, David Gurwitz, Bernhard T Baune

Translational Psychiatry | SPRINGERNATURE | Published : 2018


Lithium is the first-line treatment for bipolar affective disorder (BPAD) but two-thirds of patients respond only partially or not at all. The reasons for this high variability in lithium response are not well understood. Transcriptome-wide profiling, which tests the interface between genes and the environment, represents a viable means of exploring the molecular mechanisms underlying lithium response variability. Thus, in the present study we performed co-expression network analyses of whole-blood-derived RNA-seq data from n = 50 lithium-treated BPAD patients. Lithium response was assessed using the well-validated ALDA scale, which we used to define both a continuous and a dichotomous measu..

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University of Melbourne Researchers


Awarded by Royal Adelaide Hospital Research Foundation

Awarded by US Israel Binational Science Foundation (BSF)

Awarded by NIMH

Funding Acknowledgements

This work was supported by a Clinical Project Grant (#1997) awarded to D.S., S.R.C., and B.T.B. by the Royal Adelaide Hospital Research Foundation. D.G. and J.R.K. were supported by the US Israel Binational Science Foundation (BSF; Grant No. 2013223). J.R.K. was also supported by the NIMH (U01 MH92758) and US Department of Veterans Affairs.