Journal article
Clozapine and Psychosocial Function in Schizophrenia: A Systematic Review and Meta-Analysis
AT Olagunju, SR Clark, BT Baune
CNS Drugs | ADIS INT LTD | Published : 2018
Abstract
Background: Clozapine has unique efficacy for symptoms in treatment-resistant schizophrenia; however, symptomatic remission is not necessary nor sufficient for functional improvement. No study has pooled the effect of clozapine on psychosocial function across clinical trials. Objective: We conducted a systematic review and meta-analysis to compare the effects of clozapine with other antipsychotics on psychosocial function, and described the predictors of functional outcome. Methods: We searched MEDLINE/PubMed, PsychINFO, EMBASE, CINAHL, Scopus, Web of Science, Cochrane Central Register of controlled trials and clinical trial registries till April 2018, with no language limits. Eligible studi..
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Funding Acknowledgements
Andrew T. Olagunju is supported by an Australian Government Research Training Program Scholarship. Scott R. Clark has received a grant from the Lundbeck Institute outside the submitted work. Bernhard T. Baune has received a Grant from the National Health and Medical Research Council, Australia outside the submitted work.